Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetProteasome

Product does not compete with ATP.

General description

Fluorogenic proteasome substrate. Also acts as a substrate for calpain, chymotrypsin, and ingensin.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Anderson, M., et al. 1999. Exp. Eye Res.69, 129.Rock, K.L., et al. 1994. Cell 78, 761.Tsubuki, S., et al. 1993. Biochem. Biophys. Res. Commun.196, 1195.Sasaki, T., et al. 1984. J. Biol. Chem. 259, 12489.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sequence

Suc-Leu-Leu-Val-Tyr-AMC

Specificity

Inhibits serine proteases and cysteine proteases.

Warning

Toxicity: Standard Handling (A)